Article
[Genetics of kidney diseases and renal fibrosis].
Bulletin de l'Academie nationale de medecine - 1 Jan 1999
Grünfeld J P, Chauveau D, Joly D, Oualim Z
Abstract excerpt
Renal fibrosis is found in genetic kidney diseases. In some of them, fibrosis may be due to mechanisms not dependent on the gene defect. In other cases, fibrosis depends more specifically on the gene defect: e.g. in juvenile nephronophthisis where interstitial fibrosis predominates, or in Alport's syndrome where glomerulosclerosis is triggered probably by unbalanced distribution of alpha chains of type IV...
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