Article
Refinement of the dentinogenesis imperfecta type II locus to an interval of less than 2 centiMorgans at chromosome 4q21 and the creation of a yeast artificial chromosome contig of the critical region.
Journal of dental research - 1 Jun 1999
Aplin H M, Hirst K L, Dixon M J
Abstract excerpt
Dentinogenesis imperfecta type II is an autosomal-dominant disorder of dentin formation which has been mapped to the 6.6 centiMorgan D4S2691-D4S2692 interval at human chromosome 4q21. In the current investigation, the use of four short tandem repeat polymorphisms has allowed the critical region to be refined to an interval of less than 2 centiMorgans defined by recombination events in unrelated, affected...
Topics
- Chromosome Mapping
- Chromosomes, Human, Pair 4
- Contig Mapping
- DNA
- Dentinogenesis Imperfecta
- Extracellular Matrix Proteins
- Female
- Genes, Dominant
- Genetic Linkage
- Humans
- Integrin-Binding Sialoprotein
- Male
- Pedigree
- Phenotype