Article
Progression of cardiomyopathy and neuropathy after liver transplantation in a patient with familial amyloidotic polyneuropathy caused by tyrosine-77 transthyretin variant.
Liver transplantation and surgery : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society - 1 May 1999
García-Herola A, Prieto M, Pascual S, Berenguer M, López-Viedma B, Mir J, Vilchez J J, Berenguer J
Abstract excerpt
Familial amyloidotic polyneuropathy is an inherited form of amyloidosis associated with a mutant form of a protein called transthyretin. The Methionine-30 variant is the most frequent mutation observed. This disorder is caused by deposition of this protein as amyloid in several organs, such as the heart, kidneys, and peripheral nervous system. The disease is always progressive and fatal, and patients die 7 to 10...
Topics
- Amyloid Neuropathies
- Amyloidosis
- Cardiomyopathies
- Disease Progression
- Humans
- Liver Transplantation
- Male
- Middle Aged
- Mutation
- Prealbumin
- Tyrosine