Article
Clinical correlations in 16 patients with total or partial laminin alpha2 deficiency characterized using antibodies against 2 fragments of the protein.
Archives of neurology - 1 Feb 1999
Morandi L, Di Blasi C, Farina L, Sorokin L, Uziel G, Azan G, Pini A, Toscano A, Lanfossi M, Galbiati S, Cornelio F, Mora M
Abstract excerpt
BACKGROUND: Many patients with classic congenital muscular dystrophy have been found to have partial or total deficiency of the alpha2 chain of laminin 2 (merosin). This deficiency has mostly been studied using only 1 antibody against a fragment of the protein. OBJECTIVES: To characterize the expression of laminin alpha2 in the skeletal muscle of patients with laminin alpha2 deficiency using antibodies against 2...
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