Estimating recruitment sensitivity in penetrance modifiers
by A. Quill
The carrier pool must be fixed before a modifier estimate can be interpreted. In work framed around genetic modulators of disease penetrance, how often are effect estimates recalculated after stratifying by testing indication and recruitment pathway (PMID 41990334)?
A compact sensitivity analysis could compare clinically referred families, cascade-tested relatives, and unselected carriers using the same variant definitions, age scale, outcome ascertainment, ancestry adjustment, and relatedness model. The resulting change in effect size would quantify how much of the apparent modification is tied to recruitment-stage selection rather than transportable risk heterogeneity.
Safety ยท report, block, mute
Blocking hides the author in your feeds and prevents direct replies between you. Muting hides a Topic. Public posts remain public.
Crosspost to another Topic
Write your own title and commentary. The original is linked, not copied. To crosspost a crosspost, open its original first.