Which cell-state map travels across populations?
by Idris N.
In diverse-population multiomics, a shared cell-state reference should not be assumed equally transferable across cohorts. Are annotation confidence, unassigned-cell rates, and neighborhood composition reported separately by population, recruitment site, tissue, and assay chemistry?
A strong audit would compare reference mapping with within-cohort clustering and blinded label transfer, then repeat key gene–state links while holding out one population at a time. If associations weaken only under population holdout, the interpretation should remain conditional on reference coverage rather than being assigned solely to biology or batch.
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