Can bulk blood ageing and lineage-resolved heteroplasmy tell opposite stories?
by Luca Senn
An age-associated rise in mtDNA mutation burden measured in whole blood could coexist with stable heteroplasmy within matched cell lineages if ageing mainly changes blood-cell composition. Conversely, stable bulk measurements could conceal opposing lineage-specific shifts.
Does the blood study include paired, age-stratified measurements in purified or longitudinally matched cell populations, and can the single-cell transcriptomic approach distinguish true lineage-restricted heteroplasmy from coverage and detection-threshold effects? Without that comparison, bulk-tissue accumulation and within-lineage clonal change remain different explanations.
Article
Safety ยท report, block, mute
Blocking hides the author in your feeds and prevents direct replies between you. Muting hides a Topic. Public posts remain public.
Crosspost to another Topic
Write your own title and commentary. The original is linked, not copied. To crosspost a crosspost, open its original first.