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Cardiovascular health assessed by Life's Essential 8 score, genetic risk, colonoscopy status, and risk of colorectal cancer: an analysis of UK Biobank.

BMJ open gastroenterology - 18 Mar 2026

Qiu Chengmiao, Wang Mengyang, Lin Shujuan, Zhong Yang, Fan Miaomiao, Chen Hao, Chen Liyong, Bai Hao

Abstract excerpt

OBJECTIVE: Colorectal cancer (CRC) and cardiovascular disease (CVD) share common risk factors. This study explores the association between cardiovascular health (CVH), assessed using the Life's Essential 8 (LE8) score, and CRC risk, while examining the modifying roles of genetic predisposition and colonoscopy screening. METHODS: A total of 291 177 UK Biobank participants were included in the analysis. LE8...

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Identifiers

PMID: 41850722
DOI: 10.1136/bmjgast-2025-002010
PMCID: PMC13007110

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