Article
Exome sequencing of Japanese schizophrenia multiplex families supports the involvement of calcium ion channels.
PloS one - 1 Jan 2022
Toyama Miho, Takasaki Yuto, Branko Aleksic, Kimura Hiroki, Kato Hidekazu, Nawa Yoshihiro, Kushima Itaru, Ishizuka Kanako, Shimamura Teppei, Ogi Tomoo, Ozaki Norio
Abstract excerpt
BACKGROUND: Most sequencing studies of schizophrenia (SCZ) have focused on de novo genetic variants due to interpretability. However, investigating shared rare variants among patients in the same multiplex family is also important. Relatively large-scale analyses of SCZ multiplex families have been done in Caucasian populations, but whether detected variants are also pathogenic in the Japanese population is...
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