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Article

Activity of Auranofin against Multiple Genotypes of Naegleria fowleri and Its Synergistic Effect with Amphotericin B In Vitro.

ACS chemical neuroscience - 19 Aug 2020

Escrig Jose Ignacio, Hahn Hye Jee, Debnath Anjan

Abstract excerpt

Primary amebic meningoencephalitis, caused by brain infection with a free-living ameba, Naegleria fowleri, leads to extensive inflammation of the brain and death within 3-7 days after symptoms begin. Treatment of primary amebic meningoencephalitis relies on amphotericin B in combination with other drugs, but use of amphotericin B is associated with severe adverse effects. Despite a fatality rate of over 97%,...

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PMID: 32392039
DOI: 10.1021/acschemneuro.0c00165
PMCID: PMC7442663

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