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Article

Tryptophan hydroxylase 2 (TPH2) haplotypes predict levels of TPH2 mRNA expression in human pons.

Molecular psychiatry - 1 May 2007

Lim J-E, Pinsonneault J, Sadee W, Saffen D

Abstract excerpt

Tryptophan hydroxylase isoform 2 (TPH2) is expressed in serotonergic neurons in the raphe nuclei, where it catalyzes the rate-limiting step in the synthesis of the neurotransmitter serotonin. In search for functional polymorphisms within the TPH2 gene locus, we measured allele-specific expression of TPH2 mRNA in sections of human pons containing the dorsal and median raphe nuclei. Differences in allelic mRNA...

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Identifiers

PMID: 17453063
DOI: 10.1038/sj.mp.4001923

Genes

TPH2

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