Article
Orphan kinesin NOD lacks motile properties but does possess a microtubule-stimulated ATPase activity.
Molecular biology of the cell - 1 Dec 2001
Matthies H J, Baskin R J, Hawley R S
Abstract excerpt
NOD is a Drosophila chromosome-associated kinesin-like protein that does not fall into the chromokinesin subfamily. Although NOD lacks residues known to be critical for kinesin function, we show that microtubules activate the ATPase activity of NOD >2000-fold. Biochemical and genetic analysis of two genetically identified mutations of NOD (NOD(DTW) and NOD("DR2")) demonstrates that this allosteric activation is...
Topics
- Adenine
- Adenosine Diphosphate
- Adenosine Triphosphatases
- Amino Acid Sequence
- Animals
- Catalytic Domain
- Drosophila
- Drosophila Proteins
- Kinesins
- Kinetics
- Microtubule Proteins